Case Study Preclinical and Early Clinical Outcome Projection

The head of strategic marketing of a major pharmaceutical company
hired L&C to:

  • Provide facts and evidence for clinical outcome of one of the client´s compounds in order to support the development of the long-term strategy:
    • assess the potential of one of the client´s compounds in the context of current competition
    • benchmarking of competitors´ development pipelines, based on preclinical and clinical data
Case Study Pre-clinical and Early Clinical Outcome Projection

Method

  • Data entry of 53 clinical studies and 69 studies in animals (in six different animal species)
  • Assessment of 24 compounds in two different indications (20 preclinical, four clinical)
  • > 180 different analyses performed

Results

  • Identification of the most predictive animal model
  • Identification of the most predictive model parameters, i.e. preclinical endpoints correlated with clinical success: benchmarking of the client’s compounds against present and future competitor compounds
  • Identification of the most important endpoints and endpoint categories

Key Benefits

  • Demonstration of superior efficacy of the client’s compounds in relation to all competitors analyzed
  • Low potential of competitor entry into first indication within the next six years; competitor entry expected in the second indication within next three years
  • Label expansion program into sub-indications initiated
  • Potential huge increase of revenues